Clomid is an anti-estrogen of a non-steroidal structure, the effect of which is due to specific binding to estrogen receptors of the ovaries and pituitary gland. With a low content of estrogen in the body, it exhibits a moderate estrogenic effect, with a high content – an antiestrogenic effect. In small doses, it enhances the secretion of gonadotropins (prolactin, FSH and LH), stimulates ovulation. In large doses, it inhibits the secretion of gonadotropins. Gestagenic and androgenic activity does not possess.
Why would a doctor prescribe Clomid?
Clomid is prescribed for infertility:
- anovulatory infertility (ovulation induction);
- dysfunctional metrorrhagia;
- amenorrhea (hypogonadotropic form);
- secondary amenorrhea;
- post-contraceptive amenorrhea;
- galactorrhea (against the background of a pituitary tumor);
- polycystic ovary syndrome (Stein-Leventhal syndrome, androgen deficiency, oligospermia, diagnosis of disorders of the pituitary gonadotropic function).
How Clomid should be taken?
50 mg of Clomid once a day is taken to stimulate ovulation before going to bed. The therapy starts from the 5th day of the menstrual cycle. Therapy duration is 5 days (in the absence of a cycle – at any time). In effect absence (ovulation does not develop within 30 days), it is recommended to increase the dose to 150 mg/day or extend the course to 10 days. The course dose should not exceed 1 g.
Biphasic basal temperature is a key element in determining ovulation. Other factors are the average cyclic increase in LH production, the growth of serum progesterone during the middle luteinization phase, or during menstrual bleeding in women with amenorrhea. If ovulation appears, but there is no pregnancy, then you should repeat the course with the same dose. If, after ovulation, menstrual bleeding did not start, the possibility of pregnancy should be determined. This diagnosis should be excluded before a new treatment course.
Contraindications of Clomid
- Liver and/or renal failure;
- Metrorrhagia of unclear etiology;
- Ovarian cyst;
- Neoplasm of the genital organs;
- Tumor or hypofunction of the pituitary gland;
- Ovarian failure with hyperprolactinemia;
What side effects may occur while taking Clomid?
- Nervous system: dizziness, headache, drowsiness, slowing down the speed of mental and motor reactions, depression, increased irritability, insomnia.
- Digestive system: nausea, vomiting, gastralgia, flatulence, diarrhea.
- Allergic reactions: rarely – rash, allergic dermatitis, vasomotor disorders.
- Genitourinary system: rarely – polyuria, increased urination, pain in the lower abdomen, dysmenorrhea, menorrhagia, an increase in the ovary size (including cystic).
- Other: increase in body weight, face flushing, rarely – a decrease in visual acuity, alopecia, tenderness of the mammary glands.
- Symptoms: nausea, vomiting, face flushing, visual impairment.
- Treatment: drug withdrawal (overdose symptoms go away on their own).